GATA4 CLIA Kit for Human(Homo sapiens) | EIAab.comGATA4 CLIA Kit for Human(Homo sapiens)

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GATA4 (Gene name),

Transcription factor GATA-4 (Protein name ), GATA4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

GATA4;

Protein name:

Transcription factor GATA-4;

Alternative:

GATA-binding factor 4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1 (By similarity). Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes.

Function:

Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

442

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

442:

SALKLSPQGY | ASPVSQSPQT | SSKQDSWNSL | VLADSHGDII | TA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.243987

KEGG:

hsa:2626

MIM:

187500

STRING:

9606.ENSP00000334458

SMR:

P43694

String:

P43694

Pfam:

PF00320

MIM:

600576

Uniprot:

P43694

FOR

ELISA Kit for Human Transcription factor GATA-4

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E0374h

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ELISA Kit for Human Transcription factor GATA-4

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E0374c

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96T

ELISA Kit for Human Transcription factor GATA-4

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E0374m

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96T

ELISA Kit for Human Transcription factor GATA-4

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E0374r

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96T

ELISA Kit for Human Transcription factor GATA-4

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E0374d

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96T

CLIA Kit for Human Transcription factor GATA-4

Cat.:

U0374c

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96T

CLIA Kit for Human Transcription factor GATA-4

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U0374r

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96T

CLIA Kit for Human Transcription factor GATA-4

Cat.:

U0374h

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96T

CLIA Kit for Human Transcription factor GATA-4

Cat.:

U0374m

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96T

CLIA Kit for Human Transcription factor GATA-4

Cat.:

U0374d

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96T

Polyclonal Antibody for Human Transcription factor GATA-4

Cat.:

P0374Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Transcription factor GATA-4

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P0374Rb-m

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Polyclonal Antibody for Human Transcription factor GATA-4

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P0374Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Transcription factor GATA-4

Monoclonal Antibody for Human Transcription factor GATA-4

Cat.:

M0374h

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40ug

Monoclonal Antibody for Human Transcription factor GATA-4

Cat.:

M0374m

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40ug

Monoclonal Antibody for Human Transcription factor GATA-4

Cat.:

M0374r

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40ug

Monoclonal Antibody for Human Transcription factor GATA-4

Protein for Human Transcription factor GATA-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA."
Huang W.Y. , Cukerman E. , Liew C.C.
Gene155:219-223(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Heart.
2.

Palaszewski I. , Dame C.
Submitted (2004-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Heart.
tissue: Lung.
5.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
6.

"Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes."
Sunagawa Y. , Morimoto T. , Takaya T. , Kaichi S. , Wada H. , Kawamura T. , Fujita M. , Shimatsu A. , Kita T. , Hasegawa K.
J. Biol. Chem.285:9556-9568(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CARDIAC HYPERTROPHY;IDENTIFICATION IN COMPLEX WITH CCNT1; EP300 AND GATA4
7.

"Loss-of-function mutation in GATA4 causes anomalies of human testicular development."
Lourenco D. , Brauner R. , Rybczynska M. , Nihoul-Fekete C. , McElreavey K. , Bashamboo A.
Proc. Natl. Acad. Sci. U.S.A.108:1597-1602(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DNA-BINDING;INTERACTION WITH NR5A1 AND ZFPM2;VARIANT TACHD ARG-221;CHARACTERIZATION OF VARIANT TACHD ARG-221
8.

"GATA4 loss-of-function mutations underlie familial tetralogy of fallot."
Yang Y.Q. , Gharibeh L. , Li R.G. , Xin Y.F. , Wang J. , Liu Z.M. , Qiu X.B. , Xu Y.J. , Xu L. , Qu X.K. , Liu X. , Fang W.Y. , Huang R.T. , Xue S. , Nemer G.
Hum. Mutat.34:1662-1671(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TBX5;VARIANTS TOF PRO-9; VAL-51 AND SER-285;CHARACTERIZATION OF VARIANTS TOF PRO-9; VAL-51 AND SER-285
9.

"Solution NMR structure of a transcription factor gata-4 from Homo sapiens, Northeast structural genomics consortium (NESG) target HR4783B."
Northeast structural genomics consortium (NESG)
Submitted (2013-07) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 262-321
10.

"GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5."
Garg V. , Kathiriya I.S. , Barnes R. , Schluterman M.K. , King I.N. , Butler C.A. , Rothrock C.R. , Eapen R.S. , Hirayama-Yamada K. , Joo K. , Matsuoka R. , Cohen J.C. , Srivastava D.
Nature424:443-447(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASD2 SER-296
11.

"Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect."
Hirayama-Yamada K. , Kamisago M. , Akimoto K. , Aotsuka H. , Nakamura Y. , Tomita H. , Furutani M. , Imamura S. , Takao A. , Nakazawa M. , Matsuoka R.
Am. J. Med. Genet. A135:47-52(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASD2 PHE-52 AND SER-296
12.

"GATA4 sequence variants in patients with congenital heart disease."
Tomita-Mitchell A. , Maslen C.L. , Morris C.D. , Garg V. , Goldmuntz E.
J. Med. Genet.44:779-783(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASD2 ALA-93; GLU-316 AND ASN-425;VARIANT VSD1 VAL-411
13.

"Spectrum of heart disease associated with murine and human GATA4 mutation."
Rajagopal S.K. , Ma Q. , Obler D. , Shen J. , Manichaikul A. , Tomita-Mitchell A. , Boardman K. , Briggs C. , Garg V. , Srivastava D. , Goldmuntz E. , Broman K.W. , Benson D.W. , Smoot L.B. , Pu W.T.
J. Mol. Cell. Cardiol.43:677-685(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASD2 CYS-296 AND MET-403;VARIANTS AVSD4 SER-163 AND VAL-346
14.

"GATA4 mutations in 486 Chinese patients with congenital heart disease."
Zhang W. , Li X. , Shen A. , Jiao W. , Guan X. , Li Z.
Eur. J. Med. Genet.51:527-535(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VSD1 VAL-6; SER-46 DEL; SER-163; LYS-359; THR-429 AND VAL-442;VARIANTS TOF ALA-118 INS AND GLN-407
15.

"A novel mutation of GATA4 in a familial atrial septal defect."
Chen Y. , Mao J. , Sun Y. , Zhang Q. , Cheng H.B. , Yan W.H. , Choy K.W. , Li H.
Clin. Chim. Acta411:1741-1745(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASD2 MET-280
16.

"Mutations of the GATA4 and NKX2.5 genes in Chinese pediatric patients with non-familial congenital heart disease."
Peng T. , Wang L. , Zhou S.F. , Li X.
Genetica138:1231-1240(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VSD1 GLN-407;VARIANT TOF SER-163
17.

"A novel mutation in GATA4 gene associated with dominant inherited familial atrial septal defect."
Chen Y. , Han Z.Q. , Yan W.D. , Tang C.Z. , Xie J.Y. , Chen H. , Hu D.Y.
J. Thorac. Cardiovasc. Surg.140:684-687(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASD2 VAL-310
18.

"A novel GATA4 mutation responsible for congenital ventricular septal defects."
Wang J. , Fang M. , Liu X.Y. , Xin Y.F. , Liu Z.M. , Chen X.Z. , Wang X.Z. , Fang W.Y. , Liu X. , Yang Y.Q.
Int. J. Mol. Med.28:557-564(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VSD1 ARG-296
19.

"A novel GATA4 loss-of-function mutation associated with congenital ventricular septal defect."
Yang Y.Q. , Li L. , Wang J. , Liu X.Y. , Chen X.Z. , Zhang W. , Wang X.Z. , Jiang J.Q. , Liu X. , Fang W.Y.
Pediatr. Cardiol.33:539-546(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VSD1 TRP-43;CHARACTERIZATION OF VARIANT VSD1 TRP-43

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